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KMID : 0861019980130010187
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Korea Journal of Herbology
1998 Volume.13 No. 1 p.187 ~ p.200
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Effect of Fructus Tribuli extract on regional cerebral blood flow and pil arterial diameter
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Abstract
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Fructus Tribuli has been used in Korea for many centuries as a therapeutic agent for cerebral disease. The effect of Fructus Tribuli on the vascular system is not known. The purpose of this study was to determine the effect of Fructus Tribuli on regional cerebral blood flow and pial arterial diameter of rats.
1. rCBF was increased by Fructus Tribuli in a dose-dependent manner.
2. Pretreatment with glibenclamide, methylene blue or indomethacin significantly inhibited Fructus Tribuli induced increase in rCBF.
3. Pial arterial diameter was increased by Fructus Tribili in a dose-dependent manner.
4. Pretreatment with glibenclamide significantly inhibited the increased in pial arterial diameter induced by Fructus Tribuli.
These results suggest that Fructus Tribuli causes a diverse response of regional cerebral blood flow(rCBF) and pial arterial diameter. The increase in rCBF is mediated by prostaglandins, cyclic GMP and K+ channel and the increase in pial arteral diameter is mediated by ATP-dependent K+ channel.
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